Pyrrolidine → tert-butyl 4-[3-carbamoyl-8-(pyrrolidin-1-yl)-1H-pyrazolo[4,3-h]quinazolin-1-yl]piperidine-1-carboxylate

Participants

Reaction Steps

To a solution of tert-butyl 4-[3-carbamoyl-8-(methylsulfonyl)-1H-pyrazolo[4,3-h]quinazolin-1-yl]piperidine-1-carboxylate 30 mg (0.063 mmol) in THF (3 ml), pyrrolidine 70 μl (1 mmol) was added. The solution was stirred at room temperature for 1 hour and monitored by LC/MS. The reaction mixture was cooled to room temperature; the separated solid was filtered and washed with diethyl ether to afford tert-butyl 4-[3-carbamoyl-8-(pyrrolidin-1-yl)-1H-pyrazolo[4,3-h]quinazolin-1-yl]piperidine-1-carboxylate 15 mg (50%). LC/MS (m/z): 475.0 [M+H]+, HPLC (254 nm) method 4 Rt 2.01 min.

Provenance & Evidence