反应详情

2-bromo-4-(4-methylpiperazin-1-yl)phenyl acetate 280 mg (1.03 mmol) were dissolved in methanol and reacted with 2 ml of 1 N NaOH. After two hours the reaction was acidified with glacial acetic acid, evaporated and purified on silica with DCM/MeOH 9/1 0.4% 7M NH3 in MeOH. LC/MS (m/z): 273.2 [M+H]+, HPLC (254 nm) method 3 Rt 2.96 min.

1. customevaporated
2. custompurified on silica with DCM/MeOH 9/1 0.4% 7M NH3 in MeOH