Acetic Acid → HCID 67973461, compound

HRID 45809Notes

Reaction equation

HRID 45809 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[CH:7][C:6]=1[Br:18])(=O)C.[OH-].[Na+].C(O)(=O)C>CO>[Br:18][C:6]1[CH:7]=[C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[CH:9]=[CH:10][C:5]=1[OH:4]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 679736642-Bromo-4-(4-methylpiperazin-1-yl)phenyl acetate

Product 1

HCID 67973461HCID 67973461, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-bromo-4-(4-methylpiperazin-1-yl)phenyl acetate 280 mg (1.03 mmol) were dissolved in methanol and reacted with 2 ml of 1 N NaOH. After two hours the reaction was acidified with glacial acetic acid, evaporated and purified on silica with DCM/MeOH 9/1 0.4% 7M NH3 in MeOH. LC/MS (m/z): 273.2 [M+H]+, HPLC (254 nm) method 3 Rt 2.96 min.

Workup

  1. customevaporated
  2. custompurified on silica with DCM/MeOH 9/1 0.4% 7M NH3 in MeOH

Sources & evidence

ORD record
ord-c6643483d84745b4946092962a1949c5
Source dataset
uspto-grants-2013_09
Patent number
US08541576B2

Reaction notes

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