HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 4581Generated: October 25, 2026
Ethanol → 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-ethoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
https://huagongshe.com/reaction/4581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | 2-(4-Acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate | HCID 57315737 | — |
| Product | 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-ethoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 20151208 | 75% |
Reaction Steps
12.28 g (0.03 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 3.85 (0.03 moles) of ethyl 3-aminocrotonate are heated under reflux in 30 ml of ethanol for 8 hours. The solution is then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-ethoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as yellow crystals melting--after recrystallisation in ethanol--at 198°-200° C. The yield is 75% of the theoretical yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04727066 |
|---|
| Source dataset | uspto-grants-1988_02 |
|---|
| ORD ID | ord-dc1538eb82734bd38e7cfa4b9f6cdea5 |
|---|
| Source note | uspto-grants-1988_02 |
|---|
