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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 458113생성일: 2026년 10월 25일

Sodium Hydroxide → 3-(5-{4-[4-(3-Fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoic acid

https://huagongshe.com/reaction/458113

반응식

참여 물질

역할이름HCID투입량
반응물Sodium HydroxideHCID 14798—
반응물Ethyl 3-(5-{4-[4-(3-fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoateHCID 68874066—
용매TetrahydrofuranHCID 8028—
생성물3-(5-{4-[4-(3-Fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoic acidHCID 6887472997%

반응 단계

Prepared according to Procedure H utilizing ethyl 3-(5-{4-[4-(3-fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoate ( 0.50 g) and aqueous sodium hydroxide (2M, 2 mL) in THF (6 mL) to afford the title compound ( 0.46 g). Electrospray MS m/z 516 (MH+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07189734B2
출처 데이터셋uspto-grants-2007_03
ORD IDord-ee908c40a40d49c9a1f87a12a4449e13
출처 메모uspto-grants-2007_03