HCID 18441751, compound → HCID 18441738, compound

HRID 458148Notes

Reaction equation

HRID 458148 reaction equation
C([N:8]1[CH2:23][CH2:22][C:11]2([N:15]([CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:14][NH:13][C:12]2=[O:21])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:19][CH:18]([CH3:20])[CH2:17][CH2:16][N:15]1[C:11]2([CH2:22][CH2:23][NH:8][CH2:9][CH2:10]2)[C:12](=[O:21])[NH:13][CH2:14]1

Participants

5

Reactant 2

HCID 18441751HCID 18441751, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18441738HCID 18441738, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 130 mg (0.412 mmol) 8-benzyl-1-(3-methyl-butyl)-1,3,8-triaza-spiro[4.5]decan-4-one in 2 ml methanol was debenzylated with hydrogen in presence of 30 mg 10% Pd/C at ambient temperature over night. Then the reaction mixture was filtered through a silica gel pad and the filtrate evaporated: 70 mg 1-(3-methyl-butyl)-1,3,8-triaza-spiro[4.5]decan-4-one as colorless solid: m.p. 103–105° C., MS (ISP): 226.3 MH+.

Workup

  1. filtrationThen the reaction mixture was filtered through a silica gel pad
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-873eaa33e58049cb816a3b17c0774e47
Source dataset
uspto-grants-2007_03
Patent number
US07189850B2

Reaction notes

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