反应详情

To 1-(3-{4-pyridin-4-yl-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-3-yl}-phenyl)-3-(4-trifluoromethyl-phenyl)-urea (50 mg, 0.09 mmol) in methylene chloride (1 mL) p-toluenesulfonic acid (PTSA) (25.8 mg, 0.13 mmol) was added, the reaction was stirred at room temperature for two days. The solvent was removed under reduced pressure and the product was isolated by silica gel column chromatography (DCM/methanol 93:7).

1. customThe solvent was removed under reduced pressure
2. customthe product was isolated by silica gel column chromatography (DCM/methanol 93:7)