反应详情

To 4-(4-pyridin-4-yl-3-{3-[3-(4-trifluoromethyl-phenyl)-ureido]-phenyl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (100 mg, 0.16 mmol) in dioxane (2 mL) HCl 4M in dioxane (1 mL, 3.30 mmol) was added. After one hour the reaction was diluted with ethyl acetate (50 mL) and washed with saturated NaHCO3 solution (3×50 mL) and brine (1×50 mL). The organic phase was dried over Na2SO4, filtered and the solvent was evaporated under reduced pressure. The deprotected urea was isolated by reverse phase chromatography.

1. washwashed with saturated NaHCO3 solution (3×50 mL) and brine (1×50 mL)
2. dry with materialThe organic phase was dried over Na2SO4
3. filtrationfiltered
4. customthe solvent was evaporated under reduced pressure