Sertraline → Sertraline Hydrochloride

Participants

Reaction Steps

A solution of 50 g of sertraline base in 200 ml of n-propanol is treated with one equivalent of pyridine hydrochloride at 50° C., under a nitrogen atmosphere, for about half an hour. The mixture is allowed to reach room temperature. At about 45° C. a gel begins to precipitate which fluidifies rapidly and transforms into a crystalline solid. Agitation is maintained for 1 hour at room temperature. The solid is filtered, washed and dried under vacuum. 52 g of sertraline hydrochloride form II (yield 93%) are obtained.

Provenance & Evidence