Ammonia → Sertraline Hydrochloride

Participants

Reaction Steps

In a solution of sertraline base (50 g) in ethyl acetate/water 10/1 (400 ml), ammonium chloride (8,7 g) was added. The resulting mixture was heated at reflux temperature and stirred for 15 hours during which ammonia evolution was observed and a white crystalline solid precipitated. When the evolution of ammonia ended the solid product was filtered, washed with ethyl acetate and dried under vacuum. 50,5 g of sertraline hydrochloride form I (yield 90%) were obtained.

Provenance & Evidence