Sertraline → Sertraline Hydrochloride

Participants

Reaction Steps

A solution of sertraline base (51,7 g) in etanol (200 ml) was diluted with water (50 ml) and pyridine hydrochloride (19,5) was added at room temperature under nitrogen. The reaction mixture was stirred at room temperature for 1 hour and the solid that crystallised was isolated by filtration, washed with etanol and dried under vacuum. 50 g of sertraline hydrochloride form V (yield 87%) were obtained.

Provenance & Evidence