Sertraline → Sertraline Hydrochloride

Participants

Reaction Steps

A solution of sertraline base (50 g) in propan-2-ol (200 ml) was diluted with water (50 ml) and pyridine hydrochloride (18,9 g) was added at room temperature under nitrogen. The reaction mixture was stirred at room temperature for 1 hour and the solid that crystallised was isolated by filtration, washed with propan-2-ol and dried under vacuum. 49,2 g of sertraline hydrochloride form V (yield 88%) were obtained.

Provenance & Evidence