反应详情

Vanillin (23 g, 0.15 mol) is added to a solution of hydroxy-(4-methoxy-phenyl)-acetic acid hydrazide (30 g, 0.15 mol) in 300 ml of ethanol at room temperature. After heating this mixture to reflux for 4 hours, the reaction is poured on water and extracted with ethyl acetate. The combined organic layer is washed with brine, dried over magnesium sulfate and evaporated. The residue, which is hydroxy-(4-methoxy-phenyl)-acetic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide, is sufficiently pure to be directly used in the next step.

1. temperatureAfter heating this mixture
2. temperatureto reflux for 4 hours
3. additionthe reaction is poured on water
4. extractionextracted with ethyl acetate
5. washThe combined organic layer is washed with brine
6. dry with materialdried over magnesium sulfate
7. customevaporated