HRID4583

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

结构：CC(=O)Nc1ccc(OCCOC(=O)CC(=O)C=Cc2cccc([N+](=O)[O-])c2)cc1

HCID57315737

未命名化合物

HCID86741409

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1ccc(OCCOC(=O)C2=C(C)NC(C)=C(C(=O)OCCSC(C)C)C2c2cccc([N+](=O)[O-])c2)cc1

HCID20151218

未命名化合物

收率 42%

CONDITIONS

反应条件

温度: -5 °C

PROCEDURE

实验过程

12 g (0l03 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenylidene)acetylacetate and 5.92 g (0.03 moles) of 2-isopropylthioethyl 3-aminocrotonate are heated under reflux in 30 ml of ethanol for 8 hours. The solution is then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-isopropylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as yellow crystals melting--after recrystallisation in aqueus ethanol--at 142°-144° C. The yield was 42% of the theoretical yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d3063e5ebfc341bb90d8962965943e78
来源数据集: uspto-grants-1988_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04727066
来源说明: uspto-grants-1988_02

反应 SMILES

[N+:1]([C:4]1[CH:5]=[C:6](C=C[CH:30]=1)[CH:7]=[CH:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:27])[CH3:26])=[CH:20][CH:19]=1)=[O:13])=O)([O-:3])=[O:2].[NH2:31]/[C:32](/[CH3:43])=[CH:33]\[C:34]([O:36][CH2:37][CH2:38][S:39][CH:40]([CH3:42])[CH3:41])=[O:35].[CH2:44](O)[CH3:45]>>[CH3:44][C:45]1[NH:31][C:32]([CH3:43])=[C:33]([C:34]([O:36][CH2:37][CH2:38][S:39][CH:40]([CH3:41])[CH3:42])=[O:35])[CH:9]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:30]=2)[C:11]=1[C:12]([O:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([NH:24][C:25](=[O:27])[CH3:26])=[CH:22][CH:23]=1)=[O:13]