HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 45832Generated: October 28, 2026
Dimethylformamide dimethyl acetal → (2E)-1-(3-bromophenyl)-3-(dimethylamino)-2-pyridin-4-ylprop-2-en-1-one
https://huagongshe.com/reaction/45832
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 1-(3-Bromophenyl)-2-(pyridin-4-yl)ethan-1-one | HCID 53952423 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (2E)-1-(3-bromophenyl)-3-(dimethylamino)-2-pyridin-4-ylprop-2-en-1-one | HCID 67184764 | 93% |
Reaction Steps
Dimethylformamide dimethylacetal (15 mL) were added to a solution of 7.2 g (0.026 ol) of 1-(3-bromophenyl)-2-pyridin-4-ylethanone in 15 ml of dry tetrahydrofuran. After stirring at 65° C. for 6 hours, the solvent was removed under reduced pressure. 8 g (93% yield) of the title compound as an oil were obtained and employed in the next step without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08541575B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-ced12f8129054c63bb3cf3be4e655fa2 |
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| Source note | uspto-grants-2013_09 |
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