Pyridine → HCID 69432363, compound

Participants

Reaction Steps

A solution of 1.9 g (4.1 mmol) (2S,4R)-2-benzyloxy-methyl-4-tritylsulfanyl-pyrrolidine in 25 ml THF at 0° C. was treated with 0.57 ml (4.5 mmol) phenyl chloroformate and 0.41 ml (5.1 mmol) pyridine. After 2 h at room temperature the reaction was worked up with 1N HCl/EtOAc (3×), the organic phases were washed with H2O, aqueous saturated NaHCO3, dried and evaporated to give 2.6 g (quantitative) (2S,4R)-2-benzyloxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid phenyl ester, MS: 586 (MH+).

Provenance & Evidence