Lithium Hydroxide → HCID 9969831, compound

Participants

Reaction Steps

A solution of 0.126 g (0.3 mmol) (2R,4S)-4-acetylsulfanyl-2-(2,4,5-trifluoro-benzyloxymethyl)-pyrolidine-1-carboxylic acid tert-butyl ester in 12 ml EtOH (degased with Ar) was treated at 0° C. with 0.9 ml 1N LiOH, warmed up to room temperature and stirred for 4.5 h. The reaction was recooled to 0° C. and quenched with aqueous 10% KHSO4. The reaction was extracted with aqueous 10% KHSO4/EtOAc (3×) and the organic phase was washed with aqueous 10% NaCl, dried over Na2SO4 and evaporated to give 0.11 g (97%) (2S,4R)-4-mercapto-2-(2,4,5-trifluoro-benzyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester, MS: 378 (MH+).

Provenance & Evidence