Triethylsilane → HCID 86590060, compound

Participants

Reaction Steps

A solution of 72 mg (0.152 mmol) (2R,4R)-2-[3-(4-fluoro-phenyl)-3-oxo-propyl]-4-(4-methoxy-benzylsulfanyl)-pyrrolidine-1-carboxylic acid butyl ester and 0.12 (1.4 mmol) triethylsilane in 2.7 ml TFA was heated for 18 h at 80° C. Evaporation followed by flash chromatography on silica gel (EtOAc/hexane 7:3) gave 8 mg (15%) (2R,4R)-2-[3-(4-fluoro-phenyl)-propyl]-4-mercapto-pyrrolidine-1-carboxylic acid butyl ester, MS: 340 (MH+).

Provenance & Evidence