反应详情

120 mg (0.2 mmol) of N-tert-butyl-4-[3-{3-[(diphenylmethylidene)amino]phenyl}-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]pyridin-2-amine were dissolved in 20 ml of 1,4-dioxane and 5 ml of HCl 4M in dioxane were added. After 4 hours the solvent was removed in vacuo and the residue dissolved in dichloromethane and washed with aqueous NaHCO3. The organic layer was dried over Na2SO4 and evaporated to give, after trituration with diethylether, 40 mg (46% yield) of the title compound.

1. customAfter 4 hours the solvent was removed in vacuo
2. dissolutionthe residue dissolved in dichloromethane
3. washwashed with aqueous NaHCO3
4. dry with materialThe organic layer was dried over Na2SO4
5. customevaporated
6. customto give