Sodium Hydroxide → HCID 69433610, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3RS,4RS)-1-methanesulfonyl-pyrrolidine-3,4-dicarboxylic acid diethyl ester (1.13 g, 3.85 mmol) in THF (40 ml) was slowly added a 1 M solution of LiAlH4 in THF (11.55 ml.11.55 mmol) at 0° C. The mixture was stirred for 1.5 h at 0° C. Water (0.44 ml), 1 M aqueous NaOH (0.44 ml) and water (1.31 ml) were added subsequently at 0° C. MgSO4 was added and filtered. The solid was washed with EtOAc (4×). The filtrate was evaporated to leave a colorless solid that was washed with hot dichloromethane to give ([3RS,4RS]-4-hydroxymethyl-1-methanesulfonyl-pyrrolidin-3-yl)-methanol as a colorless solid, MS: 268 (M+OAc)−.

Provenance & Evidence