反应详情

温度

80 °C

ArgoGel-OH (45 g, 0.49 meq/g, 22 mmol) was suspended in toluene (400 mL) and tert-butyl (2S)-2-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)carbonyl]-1-pyrrolidinecarboxylate (60. g, 176 mmol) was added. The sealed reaction tube was heated at 80° C. for 23 h. The reaction mixture was allowed to cool to room temperature and filtered. The resin was washed (DMF then DCM then ether; 8× each) then dried at 40° C. overnight under high vacuum (63 g; 0.44 meq/g).

1. customThe sealed reaction tube
2. temperatureto cool to room temperature
3. filtrationfiltered
4. washThe resin was washed (DMF
5. custom8× each) then dried at 40° C. overnight under high vacuum (63 g; 0.44 meq/g)