HCID 11336866, compound → HCID 11346741, compound

HRID 458396Notes

Reaction equation

HRID 458396 reaction equation
[CH3:1][C:2]1(C)OC(=O)[CH:5]([C:9](=[O:22])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[C:4](=[O:23])[O:3]1>CCO>[O:22]=[C:9]([CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:16][CH:17]=1)[CH2:5][C:4]([O:3][CH2:2][CH3:1])=[O:23]

Participants

3

Reactant 1

HCID 11336866HCID 11336866, compound

Product 1

HCID 11346741HCID 11346741, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,2-Dimethyl-5-{3-[4-(trifluoromethyl)phenyl]propanoyl}-1,3-dioxane-4,6-dione (200 mmol) was dissolved in 500 mL absolute EtOH and refluxed for 3 h. Concentration provided the title compound as a pale yellow oil (57.35 g, 199 mmol, 99.5%, two steps): 1H NMR (400 MHz, CDCl3) δ 7.52 (d, J=8.0 Hz, 2H), 7.29 (d, J=8.0 Hz, 2H), 4.15 (m, 2H), 3.42 (s, 2H), 2.96 (m, 2H), 2.90 (m, 2H), 1.24 (t, J=7.1 Hz, 3H) ppm.

Workup

  1. temperaturerefluxed for 3 h
  2. concentrationConcentration

Sources & evidence

ORD record
ord-d91f51007bdd4ff7a861252df2a67f02
Source dataset
uspto-grants-2007_03
Patent number
US07189851B2

Reaction notes

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