反应详情

Pd(PPh3)4 (71.6 mg, 0.1 mmol) and CuI (23.6 mg, 0.1 mmol) were added to a mixture of 2,(2,5-dibromophenyl)-5-[4-octyloxy)phenyl]-1,3,4-oxadiazole (3.20 g, 6.3 mmol) and phenyl acetylene (1.29 g, 12.6 mmol) in 20 mL of dry Et3N. The reaction mixture was magnetically stirred for 3 h under reflux. The cooled reaction mixture was poured into an excess amount of methanol and the precipitate was collected by filtration. Re-crystallization from methylene chloride/hexane gave 2-(2,5-bis-phenylethynylphenyl)-5-(4-octyloxyphenyl)-[1,3,4]oxadiazole (2.50 g, 72% yield).

1. temperatureunder reflux
2. customThe cooled reaction mixture
3. filtrationthe precipitate was collected by filtration