tert-Butyl [3-(cyclopropylmethyl)-2-oxo-1,3-diazepan-1-yl]acetate → [3-(Cyclopropylmethyl)-2-oxo-1,3-diazepan-1-yl]acetic acid

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Reaction Steps

A solution of tert-butyl [3-(cyclopropylmethyl)-2-oxo-1,3-diazepan-1-yl]acetate (240 mg, 0.85 mmol) in CH2Cl2 (5 mL) and CF3CO2H (2 mL) was stirred at ambient temperature for 3 h. The mixture was concentrated in vacuo and the residue was purified by HPLC using a reversed phase C18 column and eluting with a gradient of H2O:CH3CN:CF3CO2H—90:10:0.1 to 5:95:0.1. Lyophilization provided the title compound as a clear oil. MS: m/z=227 (M+1).

Provenance & Evidence