反应详情

温度

100 °C

1 g (2.3 mmol) of 4-iodo-1-(4-methoxybenzyl)-3-(3-nitrophenyl)-1H-pyrazole (prepared as described in Example 27) were dissolved in a mixture of 20 ml of dioxane and 5 ml of water in a nitrogen atmosphere. 750 mg (2.3 mmol) of cesium carbonate, 350 mg (0.3 mmol) of palladium tetrakis and 486 mg (3.45 mmol) of 2-fluoro-pyridyl boronic acid were added and the reaction stirred at 100° C. for 4 hours. The mixture was then filtered through a celite pad and the filtrate evaporated under reduced pressure. The residue was re-dissolved with dichloromethane and washed with water. The organic layer was dried over sodium sulphate and evaporated. 680 mg (73%) of the title compound crystallized from diethylether.

1. filtrationThe mixture was then filtered through a celite pad
2. customthe filtrate evaporated under reduced pressure
3. dissolutionThe residue was re-dissolved with dichloromethane
4. washwashed with water
5. dry with materialThe organic layer was dried over sodium sulphate
6. customevaporated
7. custom680 mg (73%) of the title compound crystallized from diethylether