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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 458638Generated: October 26, 2026

1-(Bromomethyl)-2-(trifluoromethyl)benzene → 8-Bromo-3-methyl-7-(2-trifluoromethylbenzyl)-3,7-dihydropurine-2,6-dione

https://huagongshe.com/reaction/458638

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 123057—
Reactant8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dioneHCID 1548797—
Product8-Bromo-3-methyl-7-(2-trifluoromethylbenzyl)-3,7-dihydropurine-2,6-dioneHCID 2250864969%

Reaction Steps

8-Bromo-3-methyl-3,7-dihydropurine-2,6-dione and 2-(trifluoromethyl)benzyl bromide were reacted and purified as described in the General procedure G, step A, to afford 81A as white crystals in 69% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192952B2
Source datasetuspto-grants-2007_03
ORD IDord-ec64551aff234d2b9aef59de7a6d6f97
Source noteuspto-grants-2007_03