o-Xylyl bromide → 8-Bromo-3-methyl-7-(2-methylbenzyl)-3,7-dihydropurine-2,6-dione

HRID 458640Notes

Reaction equation

HRID 458640 reaction equation
[Br:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=1.[CH3:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17]Br>>[Br:1][C:2]1[N:10]([CH2:14][C:15]2[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=2[CH3:17])[C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 6992o-Xylyl bromideHCID 15487978-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione

Product 1

HCID 225086008-Bromo-3-methyl-7-(2-methylbenzyl)-3,7-dihydropurine-2,6-dione

Procedure

8-Bromo-3-methyl-3,7-dihydropurine-2,6-dione and 2-methylbenzyl bromide were reacted and purified as described in the General procedure G, step A, to afford 82A as white crystals in 79%.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-3d72132d65f341e995c356377f6c0c90
Source dataset
uspto-grants-2007_03
Patent number
US07192952B2

Reaction notes

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