HuagongsheHuagongshe Chemistry Print Report · For research reference only
{2-[4-(4-Aminobutyl)phenoxy]ethyl}carbamic acid tert-butyl ester → 4-[4-(2-Aminoethyloxy) phenyl)butylamidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {2-[4-(4-Aminobutyl)phenoxy]ethyl}carbamic acid tert-butyl ester | HCID 22566154 | — |
| Reactant | HCID 178449224 | HCID 178449224 | — |
| Product | 4-[4-(2-Aminoethyloxy) phenyl)butylamidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride | HCID 178479339 | — |
Reaction Steps
Using general procedure Z, 4-[4-(2{t-butoxycarbonylamino}ethyloxy)phenyl]butyl amine was converted into 4-[4-(2-{t-butoxycarbonylamino}ethyloxy)phenyl)]butylamidino-3,5-diamino-6-chloropyrazinecarboxamide, m.p. 118° C., APCI MS M/Z=521[C23H33ClN8O4+H]+, which was hydrolyzed and acidified with HCL to give 4-[4-(2-aminoethyloxy)phenyl)butylamidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride, m.p.>178° C. (dec), M/Z=421 [C18H25ClN8O2].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192960B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-ebc06a5aeffb4e3cadcfb14d28aaefe2 |
| Source note | uspto-grants-2007_03 |