HCID 135970954, compound → HCID 135970953, compound

Participants

Reaction Steps

Reaction of intermediate 10, 3-benzyloxy-4,8-dioxo-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidine-2-carboxylic acid ethyl ester, (0.543 g, 1.58 mmol) with trifluoroacetic acid (20 ml) as described in the preparation of intermediate 5 gave 0.296 g (74% yield) of the title ester as white crystals; mp 282° C. (dec) (ethyl acetate). 1HNMR 400 MHz (DMSO-d6) δ (ppm): 1.26 (3H, t, J=7.1 Hz, CH3), 2.66 (2H, t, J=6.8 Hz, CH2), 4.13 (2H, t, J=6.8 Hz, CH2), 4.29 (2H, q, J=7.1 Hz, OCH2), 9.94 (1H, s, NH), 11.19 (1H, broad s, OH). HRMS (FAB POS) calculated for C10H12N3O5 [M+H+]: 254.077696. found: 254.078383.

Provenance & Evidence