HCID 18442543, compound → HCID 54724255, compound

Participants

Reaction Steps

A solution of intermediate 15, N-{4-fluoro-2-(methylcarbamoyl)benzyl}-6-benzyloxy-1-methyl-2,5-dioxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyrimidine-7-carboxamide, (0.179 g, 0.37 mmol) in trifluoroacetic acid (10 ml) was stirred at 22° C. for 2 h. The solvent was then evaporated in vacuo and the residue recrystallized from ethyl acetate to give 0.114 g (78% yield) of the title amide as a white solid. 1HNMR 400 MHz (DMSO-d6) δ (ppm): 2.79 (3H, d, J=4.3 Hz, NCH3), 3.12 (3H, s, NCH3), 4.48 (2H, s, CH2), 4.58 (2H, d, J=6.3 Hz, NCH2), 7.25–7.4 (3H, m, aromatics), 8.55 (1H, broad q, NH), 9.36 (1H, broad t, NH), 12.1 (1H, s, OH). MS (ESI+) m/z 390 [M+H+].

Provenance & Evidence