4-Fluorobenzylamine → HCID 54706492, compound

Participants

Reaction Steps

Reaction of intermediate 22, ethyl 1,2-dimethyl-7-hydroxy-3,6-dioxo-2,3,4,6-tetrahydro-1H-pyrimido[2,1-c][1,2,4]triazine-8-carboxylate, (0.050 g, 0.177 mmol) with 4-fluorobenzylamine (0.11 g, 0.87 mmol) as described in the preparation of example 1 gave 0.051 g (80% yield) of the title amide as white crystals. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.27 (3H, s, NCH3), 3.30 (3H, s, NCH3), 4.61 (2H, d, J=6.3 Hz, NCH2), 4.67 (2H, s, CH2), 7.08 (2H, m, aromatics), 7.33 (2H, m, aromatics), 7.74 (1H, broad t, NH), 12.0 (1H, s, OH). MS (ESI+) m/z 362 [M+H+].

Provenance & Evidence