反应详情

温度

35 °C

To a mixture of aluminum trichloride (3.0 g, 22.5 mmol), dichloromethane (50 ml) and 2,5-dichloro-2,5-dimethylhexane (15.0 g, 81.9 mmol) is added dropwise into a solution of phenol (7.7 g, 81.90 mmol) in 50 ml of methane dichloride, then the reaction mixture is heated for 4 hours at 35° C. After cooled, the reaction mixture is poured into ice (200 g) and extracted with ether (3×80 ml). The organic phase is washed with 10% NaHCO3 solution (2×150 ml), dried over MgSO4 and evaporated to give a crude product, which is crystallized from ethanol to give the title compound (15.20 g, 84%).

1. temperatureAfter cooled
2. extractionextracted with ether (3×80 ml)
3. washThe organic phase is washed with 10% NaHCO3 solution (2×150 ml)
4. dry with materialdried over MgSO4
5. customevaporated
6. customto give a crude product, which
7. customis crystallized from ethanol