2-Naphthol → 4-[2-(2-Naphthoxy)ethoxy]benzaldehyde

HRID 458719ノート

反応式

HRID 458719 の反応式
[OH-].[K+].[CH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[OH:13].Br[CH2:15][CH2:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1>C(O)C>[CH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[O:13][CH2:15][CH2:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 86632-NaphtholHCID 14797Potassium HydroxideHCID 2627064-(2-Bromoethoxy)Benzaldehyde

生成物 1

HCID 184429064-[2-(2-Naphthoxy)ethoxy]benzaldehyde収率 36%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
-5 °C

実験手順

To a solution of potassium hydroxide (0.67 g, 9.80 mmol) in ethanol (30 ml) is added 2-naphthol (1.41 g, 9.80 mmol) and 4-(2-bromoethoxy)benzaldehyde (2.25 g, 9.80 mmol). Then the mixture is heated to reflux for 8 hours. After cooled to −5° C., the precipitate is collected by filtration, washed with water, and dried under vacuum to give the title product (1.03 g, 36%).

後処理

  1. temperatureThen the mixture is heated
  2. temperatureto reflux for 8 hours
  3. filtrationthe precipitate is collected by filtration
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-0c79e007fa3849bcaca81ee035557927
出典データセット
uspto-grants-2007_03
特許番号
US07192970B2

反応ノート

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