Fumaric Acid → HCID 20753103, compound

HRID 458739Notes

Reaction equation

HRID 458739 reaction equation
Cl.[F:2][C:3]1([F:29])[CH2:7][CH2:6][C@@H:5]([C@@:8]([OH:28])([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:9]([O:11][CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][N:17]([CH:20]=[NH:21])[CH2:16][CH2:15]2)=[O:10])[CH2:4]1.[C:30]([O-:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([O-:35])=[O:34].[Na+].[Na+].C(O)(=O)/C=C/C(O)=O>O>[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34].[F:29][C:3]1([F:2])[CH2:7][CH2:6][C@@H:5]([C@@:8]([OH:28])([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:9]([O:11][CH2:12][CH2:13][CH:14]2[CH2:15][CH2:16][N:17]([CH:20]=[NH:21])[CH2:18][CH2:19]2)=[O:10])[CH2:4]1

Participants

5

Reactant 3

HCID 444972Fumaric AcidHCID 6364607Disodium fumarateHCID 86589930HCID 86589930, compound

Product 1

HCID 20753103HCID 20753103, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of 75 mg g of 2-(1-(iminomethyl)piperidin-4-yl)-ethyl (2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylethanoate monohydrochloride in 2 ml of ultrapure water was developed on reversed phase medium pressure liquid chromatography [ODS-AQ 120-S50 (YMC Co.)], and 60 ml of 0.2 M aqueous sodium monofumarate solution, 60 ml of aqueous fumaric acid solution and 100 ml of ultrapure water were flowed by the order stated. The title compound was eluted from tetrahydrofuran/water=1/4. Condensing the same to dry solid, 41 mg of a colorless solid was obtained.

Workup

  1. washThe title compound was eluted from tetrahydrofuran/water=1/4
  2. customCondensing the same
  3. customto dry solid

Sources & evidence

ORD record
ord-fd32d6b6aa6f445683f55f8e88a7a3be
Source dataset
uspto-grants-2007_03
Patent number
US07192969B2

Reaction notes

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