1,1-Dimethylethyl 4-(3-ethoxy-3-oxo-1-propen-1-yl)-1-piperidinecarboxylate → tert-Butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

Participants

Reaction Steps

To a solution of 1.0 g of t-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-tetrahydropyridine-1(2H)-carboxylate (cf. WO9501336) in 20 ml of ethanol, 300 mg of 10% palladium-on-carbon catalyst, and stirred for 3 hours in a hydrogen atmosphere, at ambient temperature and pressure. After filtering the catalyst off, the solvent was distilled off under reduced pressure to provide 700 mg of the title compound.

Provenance & Evidence