HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydroxytetrahydropyrimidine-2(1H)-thione → 2-Thioxohexahydropyrimidin-5-yl (2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylethanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydroxytetrahydropyrimidine-2(1H)-thione | HCID 3574639 | — |
| Reactant | (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetic acid | HCID 10890505 | — |
| Product | 2-Thioxohexahydropyrimidin-5-yl (2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylethanoate | HCID 86597304 | — |
Reaction Steps
Using (2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetic acid and 5-hydroxytetrahydropyrimidine-2(1H)-thion (cf. JP-Hei01 (1989)-128970A), the title compound was prepared by a method similar to Step 2 of Referential Example 12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192969B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-91e517e563a241019511e228ed95e316 |
| Source note | uspto-grants-2007_03 |