Nitric Acid → HCID 18442574, compound

HRID 458802Notes

Reaction equation

HRID 458802 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[N+:22]([O-])([OH:24])=[O:23].O>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([C:12]2[CH:13]=[C:14]([O:20][CH3:21])[C:15]([O:18][CH3:19])=[CH:16][C:17]=2[N+:22]([O-:24])=[O:23])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 18442573HCID 18442573, compound

Product 1

HCID 18442574HCID 18442574, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent2×

Conditions

Temperature
0 °C

Procedure

A heterogeneous mixture of 2-(3,4-dichloro-phenyl)-1-(3,4-dimethoxy-phenyl)-ethanone (8.33 g, 25.6 mmol) in acetic anhydride (65 ml) was added dropwise to a cooled (0° C.) solution of 65% nitric acid (140 ml) and acetic anhydride (21.3 ml). The resulting mixture was stirred at 0° C. for 2 h. Water was added dropwise and the resulting heterogeneous mixture was allowed to stir and warm-up slowly. The crude was then filtered and the beige solid was washed several times with distilled water and dried under HV (6.98 g, 74%).

Workup

  1. additionwas added dropwise to
  2. stirringto stir
  3. temperaturewarm-up slowly
  4. filtrationThe crude was then filtered
  5. washthe beige solid was washed several times with distilled water
  6. customdried under HV (6.98 g, 74%)

Sources & evidence

ORD record
ord-a446500dc2a649cd8f0cf082ee40374f
Source dataset
uspto-grants-2007_03
Patent number
US07192950B2

Reaction notes

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