2-Bromo-1,1-difluoroethane → HCID 10281743, compound

HRID 458865Notes

Reaction equation

HRID 458865 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[CH2:6][CH:7]1[C:13]2[CH:14]=[C:15]([OH:20])[C:16]([O:18][CH3:19])=[CH:17][C:12]=2[CH2:11][CH2:10][CH2:9][N:8]1[CH2:21][C:22]([NH:24][CH:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH2:26]1)=[O:23].Br[CH2:40][CH:41]([F:43])[F:42]>>[F:42][CH:41]([F:43])[CH2:40][O:20][C:15]1[C:16]([O:18][CH3:19])=[CH:17][C:12]2[CH2:11][CH2:10][CH2:9][N:8]([CH2:21][C:22]([NH:24][CH:25]3[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27][CH2:26]3)=[O:23])[CH:7]([CH2:6][C:5]3[CH:34]=[CH:35][C:36]([O:37][CH3:38])=[C:3]([O:2][CH3:1])[CH:4]=3)[C:13]=2[CH:14]=1

Participants

3

Reactant 2

HCID 1361862-Bromo-1,1-difluoroethaneHCID 10208003HCID 10208003, compound

Product 1

HCID 10281743HCID 10281743, compound

Procedure

prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-7-methoxy-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-N-indan-1-yl-acetamide with 2-bromo-1,1-difluoroethane.

Sources & evidence

ORD record
ord-ec6791e7b3c84490b723035fc7f5208c
Source dataset
uspto-grants-2007_03
Patent number
US07192950B2

Reaction notes

Loading…