2-Bromo-1,1-difluoroethane → HCID 10146502, compound

HRID 458866Notes

Reaction equation

HRID 458866 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][NH:11][C:12](=[O:45])[CH:13]([N:20]3[CH2:26][CH2:25][CH2:24][C:23]4[CH:27]=[C:28]([O:32][CH3:33])[C:29]([OH:31])=[CH:30][C:22]=4[CH:21]3[CH2:34][C:35]3[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[C:37]([O:43][CH3:44])[CH:36]=3)[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.Br[CH2:47][CH:48]([F:50])[F:49]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][NH:11][C:12](=[O:45])[CH:13]([N:20]3[CH2:26][CH2:25][CH2:24][C:23]4[CH:27]=[C:28]([O:32][CH3:33])[C:29]([O:31][CH2:47][CH:48]([F:50])[F:49])=[CH:30][C:22]=4[CH:21]3[CH2:34][C:35]3[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[C:37]([O:43][CH3:44])[CH:36]=3)[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 1361862-Bromo-1,1-difluoroethaneHCID 10232601HCID 10232601, compound

Product 1

HCID 10146502HCID 10146502, compound

Procedure

prepared by reaction of N-benzo[1,3]dioxol-5-ylmethyl-2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-7-methoxy-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-2-phenyl-acetamide with 2-bromo-1,1-difluoroethane.

Sources & evidence

ORD record
ord-cc4ae4eb6fcb440ba48bc23287eaa68b
Source dataset
uspto-grants-2007_03
Patent number
US07192950B2

Reaction notes

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