HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → N-[4-(3-benzyl-2,4,5-trioxo-imidazolidin-1-yl)-butyl]-3-pyridin-3-yl-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 1-Benzylimidazolidine-2,4,5-trione | HCID 562619 | — |
| Reactant | N-(4-hydroxybutyl)-3-pyridin-3-yl-acrylamide | HCID 53817888 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-(3-benzyl-2,4,5-trioxo-imidazolidin-1-yl)-butyl]-3-pyridin-3-yl-acrylamide | HCID 53673377 | — |
Reaction Steps
Batch size: 4.4 g (20.0 mmol) N-(4-hydroxybutyl)-3-pyridin-3-yl-acrylamide, 5.2 g (19.8 mmol) triphenylphosphine, 4.1 g (20.1 mmol) 3-benzyl-2,4,5-trioxo-imidazolidine (production according to Ishii et al., J. Med. Chem. 39, 1924 (1996)) and 3.5 g (20.0 mmol) azodicarboxylic acid diethyl ester in 60 ml THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192967B1 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-0f0dffb5a45d4e0ab6bb87c3e9cc8092 |
| Source note | uspto-grants-2007_03 |