HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-3-pyridin-3-yl-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | N-(4-hydroxybutyl)-3-pyridin-3-yl-acrylamide | HCID 53817888 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-3-pyridin-3-yl-acrylamide | HCID 54145323 | — |
Reaction Steps
Batch size: 7.8 g (35.4 mmol) N-(4-hydroxybutyl)-3-pyridin-3-yl-acrylamide, 9.3 g (35.4 mmol) tripdhenylphosphine, 5.2 g (35.4 μmmol) phthalimide and 6.2 g (35.4 mmol) azodicarboxylic acid diethyl ester in 100 ml THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192967B1 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-abd07868b9d14f28bdbd3b7f409f121f |
| Source note | uspto-grants-2007_03 |