Methyl alpha-hydroxy-alpha-2-thienyl-2-thiopheneacetate → HCID 11742486, compound

HRID 458889Notes

Reaction equation

HRID 458889 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]([OH:15])([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]1[S:6][CH:7]=[CH:8][CH:9]=1.[CH2:17]([N:25]1[CH2:29]C[C@@H:27](O)[CH2:26]1)[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:17]([N:25]1[CH2:26][CH2:27][C@@H:1]([O:2][C:3](=[O:16])[C:4]([OH:15])([C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)[C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH2:29]1)[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 11414137Methyl alpha-hydroxy-alpha-2-thienyl-2-thiopheneacetateHCID 69479834HCID 69479834, compound

Product 1

HCID 11742486HCID 11742486, compoundYield 50.5%

Procedure

Prepared as described in Intermediate I-1 from 2-Hydroxy-2,2-dithien-2-ylacetic acid methyl ester and (3R)-1-phenethylpyrrolidin-3-ol (Intermediate I-18). The yield was 0.98 g (50.5%) of the title product.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1c5c0c5ee75a4acf93f3c3cb02fb2daa
Source dataset
uspto-grants-2007_03
Patent number
US07192978B2

Reaction notes

Loading…