HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-pyrrolidinol, (+)- → 2-Hydroxy-2,2-dithien-2-ylacetic acid (3S)-1-methylpyrrolidin-3-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-pyrrolidinol, (+)- | HCID 643504 | — |
| Reactant | Methyl alpha-hydroxy-alpha-2-thienyl-2-thiopheneacetate | HCID 11414137 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Hydroxy-2,2-dithien-2-ylacetic acid (3S)-1-methylpyrrolidin-3-yl ester | HCID 86602257 | 25% |
Reaction Steps
Prepared as described in Intermediate I-5 from 0.98 g (0.00385 mol) of 2-Hydroxy-2,2-dithien-2-ylacetic acid methyl ester in 30 ml of toluene, 0.39 g (0.00385 mol) of (3S)-1-methylpyrrolidin-3-ol (Intermediate I-20) and 0.108 g (0.0027 mol) of HNa (60% dispersion in mineral oil). The yield was 0.31 g (25%) of the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192978B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-fbcc2385c6c54bd69da4a10e3120f3cc |
| Source note | uspto-grants-2007_03 |