Lithium Hydroxide → HCID 18442475, compound

Participants

Reaction Steps

To 1,1-dioxo-3-butyl-3-ethyl-5-phenyl-7-mesyl-8-ethoxycarbonylmethoxy-2,3,4,5-tetrahydro-1,5-benzothiazepine (Method 20; 46 mg, 0.085 mmol) was added THF (5 ml), water (1 ml) and LiOH (10 mg, 0.4 mmol). The reaction was stirred for 1 hour and then excess acetic acid was added to quench the reaction. Water and DCM were added and the aqueous phase was extracted three times with DCM. The combined organic phases were dried and concentrated to give the title compound 40 mg (91%). NMR 0.7–0.85 (m, 6H), 1.0–1.7 (m, 8H), 3.2 (m, 2H), 3.3 (s, 3H), 3.8 (s, 2H), 4.9 (s, 2H), 5.0 (brs, 1H), 7.05–7.15 (m, 3H), 7.3–7.4 (t, 2H), 7.5 (s; 1H), 7.6 (s, 1H).

Provenance & Evidence