Sodium Hydroxide → HCID 18442430, compound

Participants

Reaction Steps

To a solution of 1,1-dioxo-3,3-dibutyl-5-(4-chlorophenyl)-7-methylthio-8-ethoxycarbonylmethoxy-2,3,4,5-tetrahydro-1,5-benzothiazepine (Method 100; 0.195 g, 0.343 mmol) in ethanol (8 ml) was added NaOH (1.03 mmol in 0.5 ml water). The reaction mixture was stirred at room temperature for 70 min and then quenched by adding acetic acid (0.3 ml). The solvent was evaporated under reduced pressure and the residue was extracted with DCM/water. The organic layer was separated, washed with brine, dried and evaporated under reduced pressure to give the title compound 0.169 g (91%). NMR (500 MHz, CD3OD) 0.86 (t, 6H), 1.11–1.28 (m, 8H), 1.37–1.44 (m, 4H), 2.33 (s, 3H), 3.25 (s, 2H), 3.55 (s, 2H), 4.73 (s, 2H), 7.10–7.15 (m, 3H), 7.26 (s, 1H), 7.28–7.32 (m, 2H).

Provenance & Evidence