Ethyl bromoacetate → HCID 18442436, compound

Participants

Reaction Conditions

Reaction Steps

1,1-Dioxo-3,3-dibutyl-5-(4-t-butoxycarbonylaminophenyl)-8-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepine Method 107; 597 mg, 1.16 mmol) was dissolved in MeCN (20 ml), K2CO3 (480 mg, 3.5 mmol), tetrabutylammoniumbromide (54 mg, 0.17 mmol) and ethyl bromoacetate (167 μl, 1.5 mmol) was added. The mixture was heated to 60° C. overnight. The solvent was evaporated under reduced pressure. EtOAc and water was added and the water layer was extracted two times with EtOAc. The combined organic layer was washed once with brine, dried, filtered and evaporated under reduced pressure to give the title compound 0.617 g (89%). M/z 603.3.

Provenance & Evidence