反应详情

(R,S)-[3-(5-Bromopyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methanol (prepared by hydrolysis of Intermediate 9, 3.1 g) was dissolved in hot methanol (25 ml), it was then separated by chiral column (Chiral Pak AS) eluting with 30%, isopropanol in hexanes. The title compound [(−) isomer, 1.5 g)] which eluted first from the column was collected along with the (+) isomer (second peak, 1.18 g). Chiral HPLC analysis indicated <2% of the (+) isomer was present. [α]D=−125° (c=0.0076 g/ml in methanol).

1. customit was then separated by chiral column (Chiral Pak AS)
2. washeluting with 30%, isopropanol in hexanes
3. washThe title compound [(−) isomer, 1.5 g)] which eluted first from the column
4. customwas collected along with the (+) isomer (second peak, 1.18 g)