Pyridine → HCID 58758456, compound

Participants

Reaction Steps

(5R)-3-(3-Fluoro-4-{6-[(5S)-5-(hydroxymethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}phenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one (Example 1: 150 mg, 0.342 mmol), dihydrofuran-2,5-dione (83 mg, 0.83 mmol), and 4-dimethylaminopyridine (10.5 mg, 0.09 mmol) were added to DMF (2.5 ml) and pyridine (0.5 ml). The reaction was allowed to stir overnight at room temperature followed by addition to Et2O (100 ml). The precipitate was collected by filtration and washed with additional Et2O (2×20 ml). The precipitate was then suspended in CH2Cl2 (20 ml) and the precipitate was collected by filtration and then washed with additional CH2Cl2 (2×20 ml) to yield the product as a white solid (131 mg).

Provenance & Evidence