反应详情

To a suspension of 1-[2-(4-chlorophenyl)thiazol-5-yl]ethanone (5 g, 21 mmol) in methanol (100 ml) is added sodium borohydride (832 mg, 22 mmol) at room temperature. The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is quenched with saturated aqueous ammonium chloride solution (100 ml) and extracted with dichloromethane (2×150 ml). The combined organic extracts are dried over anhydrous magnesium sulfate, filtered and evaporated to dryness to give 1-[2-(4-chlorophenyl)thiazol-5-yl]ethanol (4.88 g).

1. customThe reaction mixture is quenched with saturated aqueous ammonium chloride solution (100 ml)
2. extractionextracted with dichloromethane (2×150 ml)
3. dry with materialThe combined organic extracts are dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customevaporated to dryness