4-Fluoro-4'-hydroxybenzophenone → (2S)-3-(4-{3-[4-(4-Fluoro-benzoyl)-phenoxy]-prop-1-ynyl}-phenyl)-2-methoxy-propionic acid

HRID 459082Notes

Reaction equation

HRID 459082 reaction equation
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15]Cl)=[CH:9][CH:8]=1)C.[F:20][C:21]1[CH:35]=[CH:34][C:24]([C:25]([C:27]2[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=2)=[O:26])=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:35]=[CH:34][C:24]([C:25]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH2:15][C:14]#[C:13][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:17][CH3:18])[C:4]([OH:3])=[O:19])=[CH:12][CH:11]=3)=[CH:29][CH:28]=2)=[O:26])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 1176664-Fluoro-4'-hydroxybenzophenoneHCID 58822943(2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58822979(2S)-3-(4-{3-[4-(4-Fluoro-benzoyl)-phenoxy]-prop-1-ynyl}-phenyl)-2-methoxy-propionic acid

Procedure

The title compound was prepared from (2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 5, Step A and 4-fluoro-4′-hydroxybenzophenone in a manner analogous to that described for Example 5, Step B. MS(ES) for C26H21FO[M+H]+: 433.2.

Sources & evidence

ORD record
ord-c10001cf943742afbaaed7f0e773fc7d
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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