4-Hydroxybenzophenone → HCID 10140537, compound

HRID 459108Notes

Reaction equation

C([O:3][C:4](=[O:22])[CH:5]([O:20][CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])=[CH:9][CH:8]=1)C.O[C:24]1[CH:37]=[CH:36][C:27]([C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:29])=[CH:26][CH:25]=1>>[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][C:14]#[C:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:20][CH3:21])[C:4]([OH:3])=[O:22])=[CH:12][CH:11]=2)=[CH:32][CH:31]=1)(=[O:29])[C:27]1[CH:36]=[CH:37][CH:24]=[CH:25][CH:26]=1

Participants

Reactant 2

HCID 143474-Hydroxybenzophenone

HCID 69424247HCID 69424247, compound

Product 1

HCID 10140537HCID 10140537, compound

Procedure

The title compound was prepared from 3-[4-(6-Hydroxy-hex-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 49, Step A) and 4-hydroxybenzophenone via the standard Mitsunobu coupling-hydrolysis procedure (Standard Procedure A) to produce the title compound. MS(ES) for C29H28O5 [M+H]+: 457.2.

Sources & evidence

ORD record: ord-bf41b118a1994dc38d2894796868483e
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

Loading…